Publications

US Patents & Patent Applications
— Nel, A. E.; Meng, H.; Mei, K.-C.  Nano-Enabled Immunotherapy in Cancer. U.S. Patent No.: 11,433,143 (2022)
— Nel, A. E.; Mei, K.-C., Liu, X.; Liao, Y.-P. Cxcr4 antagonist loaded liposomes and silicasomes U.S. Patent Application No. 3/277,112. World Patent Application: WO2023081514A1 (2023)

Journal Articles [Google Scholar]

In Submission, Under Review/Revision

  • Wei, P.-S.; Thota, N.; John, G.; Chang, E.; Lee, S.; Wang, Y.; Ma, Z.; Tsai, Y.-H.; Mei, K.-C.* Organ- and Cell-Specific Lipid Nanoparticles for Precision mRNA/siRNA Therapeutics (under review).

  • Salgado-Gallegos, J.; Mei, K.-C.; Binder, G.; Tejeda-Muñoz, N. Wnt signaling in colon cancer and emerging therapeutic strategies (under review).

  • Li, Y.-T.; Mei, K.-C.; Liam-Or, R.; Wang, Julie T.-W.; Nazer Faruqu, F. N.; Zhu, S.; Wang, Y.; Lu, Y.; Al-Jamal, K. T. Graphene Oxide Nanosheets Toxicity in Mice is Dependent on Protein Corona Composition and Host Immunity (under review)

28.  Jasiewicz, N. E.; Mei, K.-C.; Oh, H.; Bonacquisti, E. E.; Chaudhari, A. P.; Byrum, C.; Jensen, B.; Nguyen, J. In situ-crosslinked Zippersomes enhance cardiac repair by increasing accumulation and retention. (in revision) BioRxiv 2024, doi: 10.1101/2024.03.14.585030

27.  Tejeda-Muñoz, N.; Azbazdar. Y.; Sosa, E. A.; Monka, J.; Wei, P.-S.; Binder, G.; Mei, K.-C.; Kurmangaliyev, Y.; De Robertis, E. M. Na, K-ATPase Activity Promotes Macropinocytosis and Lysosomes in Colon Cancer via Wnt Signaling. Biology Open, 2024, bio.060269, doi: 10.1242/bio.060269

26.  Mei, K.-C.*; Thota, N.; Wei, P.-S.; Yi, B.; Bonacquisti, E.; Nguyen, J. Calreticulin P-domain-derived “eat-me” peptides for enhancing liposomal uptake in dendritic cells. International Journal of Pharmaceutics, 2024, doi: 10.1016/j.ijpharm.2024.123844.

25.  Tejeda-Muñoz, N.; Mei, K.-C. Wnt signaling in cell adhesion, development, and colon cancer. IUBMB Life, 2024, doi: 10.1002/iub.2806

24.  Mei, K.-C.*; Stiepel R. T.; Bonacquisti, E. E.; Jasiewicz, N. E.; Chaudhari, A. P.; Tiwade, P. B.; Bachelder, E. M.; Ainslie, K. M.; Fenton, O. S.; Nguyen J.  Single-tailed heterocyclic carboxamide lipids for macrophage immune-modulation. Biomaterials Science (RSC), 2023, 11(8), 2693-2698, doi: 10.1039/D2BM01804G

23.  Jasiewicz, N. E.; Mei, K.-C.; Oh, H.; Chansoria, P.; Hendy, D.; Bonacquisti, E. E.; Bachelder, E. M.; Ainslie, K. M.; Yin, H.; Qian, L.; Jensen, B. C.; Nguyen J.  ZipperCells exhibit enhanced accumulation and retention at the site of myocardial infarction. Advanced Healthcare Materials, 2023, 12(4), 2201094, doi: 10.1002/adhm.202201094 [Journal Back Cover]

22.  Tejeda-Muñoz, N.; Mei, K.-C.; Sheladiya, P.; Monka, J.  Targeting membrane trafficking as a strategy for cancer treatment. Vaccines, 2022, 17;10(5):790, doi: 10.3390/vaccines10050790.

21.  Nel, A. E.; Mei, K.-C.; Liao, Y.-P.; Liu, X.  Multi-functional lipid bilayer nanocarriers for cancer immunotherapy in heterogeneous tumor microenvironment, combining immunogenic cell death stimuli with immune modulatory drugs. ACS Nano, 2022, 16 (4), 5184–5232, doi: 10.1021/acsnano.2c01252

20.  Etter E.; Mei, K.-C.; Nguyen J.  Delivering more for less: carrier-free and pharmaco-active drug delivery systems.  Advanced Drug Delivery Review, 2021, doi: 10.1016/j.addr.2021.113994

19.  Mei, K.-C.; Costa, P. M; Kreuzer, M.; Al-Jamal, K. T.  Interpreting 2D materials bio-nano interactions: influence of aggregation status, protein corona, cell culture media, and cell types.  Advanced Materials Interfaces, 2021, 8(17), 202100251, doi: 10.1002/admi.202100251 [Journal Frontispiece Cover]

18.  Shih, P.-C.; Mei, K.-C. Role of STAT3 Signaling transduction pathways in cancer stem cell-associated chemoresistance. Drug Discovery Today, 2021, 26(6), 1450-1458, doi: 10.1016/j.drudis.2020.11.032

17.        Li. J.; Guiney, L. M.; Downing, J. R.; Wang, X.; Chang, C. H.; Jiang, J.; Liu, Q.; Liu, X.; Mei, K.-C.; Liao, Y.-P.; Ma, T.; Meng, H.; Hersam, M. C.; Nel, A. E.; Xia, T. Dissolution of 2D molybdenum disulfide generates differential toxicity among liver cell types compared to non-toxic 2D boron nitride effects. Small, 2021, 17(14), 21740065, doi: 10.1002/smll.202170065

16.        Li, J.; Wang, X; Mei, K.-C.; Chang, C. H.; Jiang, J; Liu, X; Liu, Q; Guineyd, L.; Hersamd, M.; Meng, H.; Xia, T. Lateral size of graphene oxide determines differential cellular uptake and cell death pathways in Kupffer cells, LSECs, and hepatocytes. Nano Today, 2021, 37, 101061, doi: 10.1016/j.nantod.2020.101061

15.        Liu, X.; Jiang, J.; Chang, C. H.; Liao, Y.-P.; Lodico, J.; Tang, I.; Zheng, E.; Qiu, Lin, M.; Wang, X.; Ji, Y.; Mei, K.-C.; Nel, A. E.; Meng, H. Development of facile and versatile platinum drug delivering silicasome nanocarrier for efficient pancreatic cancer treatment. Small, 2021, 17(14), 2005993, doi: 10.1002/smll.202005993 [Journal Back Cover]

14.        Liu, X.; Jiang, J.; Liao, Y.-P.; Tang, I.; Zheng, E.; Qiu, W.; Lin, M.; Wang, X.; Ji, Y.; Mei, K.-C.; Liu, Q.; Chang, C. H.; Wainberg, Z. A.; Nel, A. E.; Meng, H. Combination chemo-immunotherapy for pancreatic cancer using the immunogenic effects of an irinotecan silicasome nanocarrier plus Anti-PD-1. Advanced Science, 2021, doi: 10.1002/advs.202002147

13.        Liu, Q.; Wang, X.; Liu, X.; Liao, Y.-P.; Chang, C. H.; Mei, K.-C.; Jiang, J.; Tseng, S.; Gochman, G.; Huang, M.; Thatcher, Z.; Li, J.; Allen, S. D.; Lucido, L.; Xia, T.; Nel, A. E. Antigen/epitope-delivering tolerogenic nanoparticles targeting the liver exert comparable efficacy in allergic airway disease and anaphylaxis as tolerogenic nanoparticles delivering pharmaceuticals. ACS Nano, 2021, 15(1), 1608-1626, doi: 10.1021/acsnano.0c09206

12.        Mei, K.-C.; Liao, Y.-P.; Jiang, J.; Chiang, M.; Khazaieli, M.; Liu, X.; Wang, X.; Liu, Q.; Chang, C. H.; Zhang, X.; Li, J.; Ji, Y.; Melano, B.; Telesca, D.; Xia, T.; Meng, H.; Nel, A. E. Liposomal delivery of mitoxantrone and a cholesteryl indoximod prodrug provides effective chemo-immunotherapy in multiple solid tumors. ACS Nano, 2020, 14(10), 13343-13366, doi: 10.1021/acsnano.0c05194

11.        Costa, P. M.;^ Mei, K.-C.;^ Kreuzer, M.; Lee, Y.; H. A. Neveen; Vivian, G.; Frederic, F.; Steven, P.; Al-Jamal, KT. Selective toxicity of functionalized graphene oxide to patients-derived glioblastoma stem cells and minimal toxicity to non-cancerous brain tissue cells. 2D Materials, 2020, 7, 045002 (^equal contribution) [PDF], doi: 10.1088/2053-1583/ab9a0f (^equal contribution)

10. Liu, Q; Wang, X; Liu, X; Kumar, S; Gochman, G; Ji, Y; Liao, Y.-P.; Chang, C.-H.; Situ, W; Lu, J; Jiang, J; Mei, K.-C.; Meng, H; Xia, T; Nel, A. E. Use of Polymeric Nanoparticle Platform Targeting the Liver to Induce Treg-Mediated Antigen-Specific Immune Tolerance in a Pulmonary Allergen Sensitization Model. ACS Nano, 2019, 13(4), 4778-4794 [PDF], doi: 10.1021/acsnano.9b01444

9.  Mei, K.-C.; Ghazaryan, A.; Teoh, E. Z.; Summers, H. D.; Li, Y.; Ballesteros, B; Piasecka, J.; Walters, A.; Hider, R. C.; Mailänder, V.; Al-Jamal, K. T.  Protein-corona-by-design in 2D: a reliable platform to decode bio-nano interactions for the next generation quality-by-design nanomedicines.  Advanced Materials, 2018, 30, 1802732, doi: 10.1002/adma.201802732 [PDF]

8. Dubey, R. D.; Klippstein, R.; Wang, J. T.-W.; Hodgins, N.; Mei, K.-C.; Sosabowski, J.; Hider, R. C.; Abbate, V.; Gupta, P. N. & Al-Jamal, K. T. Novel hyaluronic acid conjugates for dual nuclear imaging and therapy in CD44-expressing tumour in mice in vivo. Nanotheranostic, 2017, 1(1), 59-79. [PDF], doi: 10.7150/ntno.17896

7. Mei, K.-C.; Bai, J.; Gonzalez, S.L.; Wang, J. T.-W.; Al-Jamal, K. T. Investigating the effect of tumour vascular characteristics on magnetic tumour targeting in vivo using retrospective statistical design of experiment. Biomaterials, 2016, 106, 276-285. [PDF], doi: 10.1016/j.biomaterials.2016.08.030

6. Bai, J.; Wang, J. T.-W.; Mei, K.-C.; Al-Jamal, W. T. & Al-Jamal, K.T. Real-time monitoring of magnetic drug targeting using fibered confocal fluorescence microscopy. Journal of Controlled Release, 2016, 224(B), 240-246 [PDF], doi: 10.1016/j.jconrel.2016.07.026

5. Al-Ahmady, Z.^; Lozano, N.^; Mei, K-C.^; Al-Jamal, W. & Kostarelos, K. Engineering thermosensitive liposome-nanoparticle hybrids loaded with doxorubicin for heat-triggered drug release. International Journal of Pharmaceutics, 2016, 514, 133-141 [PDF], doi: 10.1016/j.ijpharm.2016.09.009 (^equal contribution)

4. Rubio, N.^; Mei, K.-C.^; Klippstein, R.; Costa, P. M.; Hodgins, N.; Wang, J. T.-W.; Festy, F.; Abbate, V.; Hider, R. C.; Chan, K. L. A. & Al-Jamal, K. T. Solvent-free click-mechanochemistry for the preparation of cancer cell targeting graphene oxide. ACS Applied Materials & Interfaces, 2015, 7(34), 18920–18923. (^equal contribution) [PDF], doi: 10.1021/acsami.5b06250 (^equal contribution)

3. Mei, K.-C.; Rubio, N.; Costa, P. M.; Kafa, H.; Abbate, V.; Festy, F.; Bansal, S. S.; Hider, R. C. & Al-Jamal, K. T. Synthesis of double-clickable functionalised graphene oxide for biological applications. Chemical Communications, 2015, 51(81), 14981–14984. [PDF], doi: 10.1039/C5CC05412E

2. Mei, K.-C.; Guo, Y.; Bai, J.; Costa, P.; Kafa, H.; Protti, A.; Hider, R. C.; Al-Jamal, K. T. Organic solvent-free, one-step engineering of graphene-based magnetic-responsive hybrids using design of experiment-driven mechano-chemistry. ACS Applied Materials & Interfaces, 2015, 7(26), 14761-14181. [PDF], doi: 10.1021/acsami.5b03577

1. Rubio, N.; Serra-Maia, R.; Kafa, H.; Mei, K.-C.; Pach, E.; Luckhurst, W.; Zloh, M.; Festy, F.; Richardson, J. P.; Naglik, J. R.; Ballesteros, B.; Al-Jamal, K. T. Production of water-soluble few-layer graphene mesosheets by dry milling with hydrophobic drug. Langmuir, 2014, 30(49), 14999–15008. [PDF], doi: 10.1021/la5038475